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. 2020 Dec 14;10:21881. doi: 10.1038/s41598-020-78930-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The experimental scheme. On postnatal day 12 (P12), mice underwent permanent middle cerebral artery occlusion (MCAO). Two days after the injury (P14), they were administered vehicle, umbilical-cord-blood-derived CD34⁺ cells (CD34⁺), or umbilical-cord-derived mesenchymal stem/stromal cells (MSCs) intravenously (i.v.). At P15, brain samples were collected. For metabolomic analysis, brain extracts from the injured hemispheres were analyzed by CE-TOF MS, and coronal brain sections from another cohort of mice were subjected to MS imaging.