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. Author manuscript; available in PMC: 2021 Dec 15.
Published in final edited form as: Life Sci. 2020 Oct 18;263:118602. doi: 10.1016/j.lfs.2020.118602

Figure 2. The regulatory network that mediates the association between mitochondrial dysfunction and other physiological activities.

Figure 2.

ADAMTS-5: A Disintegrin And Metalloproteinase with Thrombospondin Motifs 5; AKT: RAC-alpha serine/threonine-protein kinase; AMPK: 5′ AMP-activated protein kinase; CaMKKβ: Calcium/calmodulin-dependent protein kinase kinase 2; CaN: Calmodulin; Cdc42: Cell division control protein 42 homolog; COX: cyclooxygenase; eIFs: Eukaryotic initiation factors; ERR: Estrogen-related receptor; FAR: Focal adhesion kinase; MAPK: Mitogen-activated protein kinase; MCU: Mitochondrial calcium uniporter; NAD: Nicotinamide adenine dinucleotide; NFAT: Nuclear factor of activated T-cells; NRF1/2: Nuclear respiratory factor1/2; PI3K: Phosphatidylinositol 3-kinase ; RNS: Reactive nitrogen species; SIRT1: Silent information regulator 1; STING: Stimulator of interferon genes; SOD: Superoxide dismutase; TNF-α: Tumor necrosis factor α; UPR: Unfolded protein response; VDAC1: Voltage Dependent Anion Channel 1.