Table 1.

Comparison of five p16^INK4a reporter mice models.

P16INK4a reporter mice	Genetic strategy	Reporter	Features	Refs
P16-Luc	Transgenic	Luciferase	Monitoring senescent cells timely	Yamakoshi et al., 2009
P16LUC	Knockin	Luciferase	Monitoring senescent cells timely	Burd et al., 2013
P16tdTom/+ mice	Knockin	tdTomato	1. Isolating and analyzing single senescent cell 2. Fluorescence of tdTom is six times brighter than green fluorescent protein	Liu et al., 2019
INK-ATTAC mice	Transgenic	GFP, ATTAC	1. Isolating and analyzing single senescent cell 2. Clearing senescent cells by AP20187	Baker et al., 2011
P16-3MR mice	Transgenic	Luciferase, mRFP, HSV-TK	1. Monitoring senescent cells timely. 2. Isolating and analyzing single senescent cell 3. Clearing senescent cells by GCV	Demaria et al., 2014