TABLE 1.
The expression and roles of circ-CDR1as in different human cancers.
| Cancer type | Expression | Functional roles | Related signaling pathways | References |
| Melanoma | Downregulated | Migration | CDR1as-IGF2BP3 | Sun et al., 2016; Zhang L. et al., 2018; Hanniford et al., 2020 |
| Non-small-cell lung cancer | Upregulated | Proliferation Migration Apoptosis | CDR1as-219a-5p/SOX5 | Zhang X. et al., 2018; Li Y. et al., 2020 |
| Esophageal squamous cell carcinoma | Upregulated | Proliferation Migration Autophagy | CDR1as-miR-1299-EGFR CDR1as-miR-7-KLF4 CDR1as-miR-7-HOXB13 CDR1as-miR-876-5p-MAGE-A | Li R. C. et al., 2018; Sang et al., 2018b; Huang et al., 2019; Meng et al., 2020 |
| Colorectal cancer | Upregulated | Proliferation Migration | CDR1as-miR-7/HOXB13 | Tang et al., 2017; Weng et al., 2017; Li R. C. et al., 2018 |
| Hepatocellular carcinoma | Upregulated | Proliferation Migration | CDR1as-miR-7 | Yu et al., 2016; Xu et al., 2017; Yang X. et al., 2017; Su et al., 2019 |
| Nasopharyngeal carcinoma | Upregulated | Proliferation | CDR1as—miR-7-E2F3 | Zhong et al., 2019 |
| Laryngeal squamous cell carcinoma | Upregulated | Proliferation Migration | CDR1as—miR-7-CCNE1 CDR1as-miR-7-PIK3CD | Zhang J. et al., 2018 |
| Osteosarcoma | Upregulated | Proliferation | CDR1as-miR-7 | Xu et al., 2018 |
| Cholangiocarcinoma | Upregulated | Proliferation Migration | CDR1as-miR-641 | Jiang et al., 2018; Li D. et al., 2020 |
| Gastric cancer | Upregulated | Proliferation Migration Chemoresistance | CDR1as-miR-7-PTEN CDR1as-miR-135-TRPC1 CDR1as-miR-7-5p-REGgama | Pan et al., 2018; Li C. et al., 2019; Zhang Z. et al., 2020 |
| Breast cancer | Upregulated | Proliferation Migration Chemoresistance | CDR1as—miR-1299-EGFR CDR1as-miR-7-REGγ CDR1as-miR-1299-MMPs | Sang et al., 2018a; Uhr et al., 2018; Yang et al., 2019a,b; Meng et al., 2020 |
| Ovarian cancer | Downregulated | Proliferation-inhibition Migration-Inhibition Chemosensitivity | CDR1as-miR-135B-5P CDR1as-miR-1270-SCAI | Chen et al., 2019; Zhao et al., 2019 |
| Bladder cancer | Downregulated | Proliferation-inhibition Migration-Inhibition Chemosensitivity | CDR1as-miR1270-APAF1 CDR1as-miR-135a | Li P. et al., 2018; Yuan et al., 2019 |