FIGURE 2.

Cell-to-cell communication exploration of different cell types. (A) Network view of autocrine and paracrine cell-to-cell communications within and across cell types. Autocrine signaling represents the signaling cells and the target cells that are the same or similar cells (such as belonging to the same cell type), while paracrine signaling could be the interactions between different cell types in a microenvironment. The circles and edges are in proportion to the counts of ligand–receptor interaction pairs. (B) Heatmap showing the interaction scores of ligand–receptor pairs in each cell type. Interaction scores could be the significance (e.g., P-value) or the weighted scores for ligand–receptor interactions.