FIGURE 4.

RNA velocity and chromatin accessibility analyses. (A) RNA velocity inference of single cells to predict their future transcriptional states. The velocity of gene expression could be represented as the mRNA abundance over time, which enables the prediction of future transcriptional state of cells (the arrows denote the directionality). (B) Graphic view of chromatin accessibility prediction with scRNA-seq data. Transcriptome and regulome could have bidirectional interplay because of the feedback, thus scRNA-seq has the potential to predict the chromatin accessibility of transcribed regions using the corresponding computational approach. However, it is worth noting that the chromatin accessibility of non-transcribed regions cannot be predicted with scRNA-seq.