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Application of protein engineering and structural biology based approaches in yeast monoterpenoid production. (A) Structure of (–)-LS (PDB ID 2ONG). N-terminal and C-terminal domain are colored in green and wheat, respectively. (B) Comparison of the structure of (–)-LS (colored in green) and (+)-LS (colored in blue). (C) Increasing the production of target monoterpenoid through optimizing important metabolic nodes/key enzymes by enzyme engineering or structure biology.
