Figure 5.

Putamen: Dopamine and Serotonin Signaling Tracks Choice Submission

(A) Dopamine and serotonin time series from putamen locked to the onset of the motion stimulus and overlaid onto distribution over choice reaction time (pink histogram) in participant 5. See Figure S2D for participants 1–4.

(B) Dopamine and serotonin time series from putamen locked to stimulus onset (left) or choice submission (right) and grouped by terciles over choice reaction time in participant 5.

(C) Same as in (A) but separated by choice accuracy.

(D) Same as in right-hand side of (B) but separated by choice accuracy.

In (A)–(D), time series were Z scored separately for each trial (stimulus-locked: period spanned from 1 s before stimulus onset to 5 s after stimulus onset; choice-locked: period spanned from 4 s before choice submission to 4 s after choice submission) and smoothed using a running average (.5 s). Data are represented as mean ± SEM in (A) and (C) and as mean in (B) and (D). Marker indicates that a time point is statistically different from zero (p < 0.05, one-sample t test). Top right-hand corner indicates participant number and disease state (PD: Parkinson’s disease; ET: essential tremor). DA: dopamine. 5-HT: serotonin.