Figure 3. Association of HIF-1α and Nur77 in breast cancer cells under anoxic conditions.
Protein expression of HIF-1α, Nur77 and VEGF (A) in MCF-7 cells and HIF-1α, Nur77 and p-mTOR (B) in T47D cells treated with cobalt chloride for 0, 0.5, 1, 3, 6, 9, 12, 24, 36 and 48 h. Protein expression of HIF-1α, Nur77 and mTOR (C) in MCF-7 cells and (D) T47D cells treated with different concentrations of LNT under treatment with cobalt chloride (0 and 100 μM). Abbreviation: LNT, Lentinus edodes. Data are shown as the means ± SD, n≥3.