Table 4.
Significantly Enriched GO Terms and KEGG Pathways
| Data Source | Term | Count | % | P | Genes |
|---|---|---|---|---|---|
| GO-BP | GO:0 001 501: Skeletal system development | 5 | 6.76 | 1.74E-03 | DLX6, DLX5, FGFRL1, PKDCC, MEPE |
| GO:0 032 332: Positive regulation of chondrocyte differentiation | 3 | 4.05 | 2.27E-03 | SMAD3, PKDCC, SOX6 | |
| GO:0 060 021: Palate development | 4 | 5.41 | 2.91E-03 | DLX6, DLX5, TIPARP, PKDCC | |
| GO:0 016 055: Wnt signaling pathway | 5 | 6.76 | 5.32E-03 | WNT16, SOST, WLS, AXIN1, APC | |
| GO:0 001 649: Esteoblast differentiation | 4 | 5.41 | 7.00E-03 | IBSP, DLX5, SP7, SPP1 | |
| GO:0 030 501: Positive regulation of bone mineralization | 3 | 4.05 | 7.61E-03 | SLC8A1, SMAD3, PKDCC | |
| GO:0 045 893: Positive regulation of transcription, DNA-templated | 7 | 9.46 | 1.25E-02 | FUBP3, SOST, DLX5, SMAD3, BRCA1, AXIN1, NR1H3 | |
| GO:1 904 885: Beta-catenin destruction complex assembly | 2 | 2.70 | 1.86E-02 | AXIN1, APC | |
| GO:0 045 732: Positive regulation of protein catabolic process | 3 | 4.05 | 2.13E-02 | TIPARP, AXIN1, APC | |
| GO:0 090 090: Negative regulation of canonical Wnt signaling pathway | 4 | 5.41 | 2.33E-02 | SOST, PFDN5, AXIN1, APC | |
| GO:0 007 155: Cell adhesion | 6 | 8.11 | 2.87E-02 | IBSP, MAEA, CNTNAP1, SPON2, SPP1, APC | |
| GO:0 001 503: Ossification | 3 | 4.05 | 3.63E-02 | IBSP, SOST, SPP1 | |
| GO:0 051 481: Negative regulation of cytosolic calcium ion concentration | 2 | 2.70 | 3.69E-02 | SLC8A1, SMAD3 | |
| GO:0 060 070: Canonical Wnt signaling pathway | 3 | 4.05 | 3.88E-02 | SMAD3, AXIN1, APC | |
| GO:0 048 646: Anatomical structure formation involved in morphogenesis | 2 | 2.70 | 4.05E-02 | DLX6, DLX5 | |
| GO:0 033 147: Negative regulation of intracellular estrogen receptor signaling pathway | 2 | 2.70 | 4.41E-02 | CRIPAK, BRCA1 | |
| GO:0 007 049: Cell cycle | 4 | 5.41 | 4.80E-02 | DBF4B, MAEA, BRCA1, GAK | |
| KEGG | hsa04550: Signaling pathways regulating pluripotency of stem cells | 5 | 6.76 | 1.27E-03 | WNT16, DLX5, SMAD3, AXIN1, APC |
| hsa04310: Wnt signaling pathway | 4 | 5.41 | 1.17E-02 | WNT16, SOST, AXIN1, APC | |
| hsa05217: Basal cell carcinoma | 3 | 4.05 | 1.49E-02 | WNT16, AXIN1, APC | |
| hsa04390: Hippo signaling pathway | 4 | 5.41 | 1.50E-02 | WNT16, SMAD3, AXIN1, APC | |
| hsa05210: Colorectal cancer | 3 | 4.05 | 1.94E-02 | SMAD3, AXIN1, APC |
Abbreviations: GO-BP, biological process in gene ontology; KEGG, Kyoto encyclopedia of genes and genomes; Wnt, wingless-related integration site.