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(A) Design of the experiment for CETSA MS profiling of 22 compounds in intact HepG2 cells. (B) Volcano plots summarizing proteins found to be stabilized/destabilized upon treatment of HepG2 cells with baloxavir marboxil (left), hydroxychloroquine, remdesivir, and ritonavir (right). (C) Box plot representation showing stability changes of TRIP13 and cocaine esterase CES2 relative to the vehicle control for all 22 compounds analyzed.
