Table 3.
28 TAs showed significantly differential signal intensities between lung cancer patients and cancer-free smokers.
| GenBank ID | Protein Description | Ratio* | pvalue |
|---|---|---|---|
| BC039826.1 | DEAD (Asp‐Glu‐Ala‐Asp) box polypeptide 6 (DDX6) | 43.6 | 3.36E−03 |
| NP_001419.1 | Enolase 1 (ENO1) | 33.8 | 7.36E−03 |
| BC050424.1 | F‐box protein 38 (FBXO38) | 26.2 | 2.76E−03 |
| NP_001129173.1 | 14–3–3 protein zeta (14–3–3ζ) | 19.7 | 5.60E−03 |
| NP_640,343.1 | Cancer/testis antigen 1 (CTAG1A) | 15.9 | 4.50E−03 |
| PV3665 | Casein kinase 1, delta (CSNK1D) | 12.1 | 7.32E−03 |
| CAA56734.1 | Cell surface associated Mucin 1 (MUC1) | 10.7 | 1.78E−03 |
| BC026100.2 | Testis‐specific transcript, Y‐linked 8 (TTTY8) | 8.4 | 1.80E−03 |
| BC059404.1 | B‐cell CLL/lymphoma 6, member B (BCL6B) | 7.8 | 4.01E−02 |
| NM_002742.1 | Serine/threonine‐protein kinase D1 (PRKD1) | 7.5 | 2.37E−02 |
| NP_000691.1 | Annexin 1 (ANXA1) | 6.9 | 2.86E−02 |
| BC001497.2 | RAN binding protein 5 (RANBP5) | 5.1 | 2.35E−02 |
| NM_005118.2 | tumor necrosis factor superfamily, member 15 (TNFSF15) | 4.6 | 3.21E−03 |
| BC005220.1 | Chaperonin containing TCP1, subunit 8 (theta) (CCT8) | 45.1 | 8.33E−03 |
| AAH04364.1 | Transmembrane protein 39B (TMEM39B) | 3.2 | 3.65E-02 |
| NM_006792.2 | Mortality factor 4 (MORF4) | 43.3 | 2.33E−02 |
| NM_203,454. | Putative C‐>U‐editing enzyme APOBEC‐4 (APOBEC4) | 28.3 | 1.67E−02 |
| XM_936,115.1 | HLA class II histocompatibility antigen, DQ(3) alpha chain (HLA-DQA3) | 22.6 | 2.13E-02 |
| PV3825 | Casein kinase 1, gamma 1 (CSNK1G1) | 21.9 | 1.67E−02 |
| NM_002622.3 | Prefoldin subunit 1 (PFDN1) | 17.3 | 2.63E−02 |
| NM_031966.4 | Cyclin B1 (CCNB1) | 4.7 | 2.67E−02 |
| BC033708.1 | Ral GEF with pH domain and SH3 binding motif 1 (RALGPS1) | 4.8 | 4.50E−03 |
| AAF66640.1 | Heat shock protein HSP60 (HSP60) | 40.3 | 2.38E−02 |
| NM_005517.2 | High‐mobility group nucleosomal binding domain 2 (HMGN2) | 3.5 | 8.54E−03 |
| BC041157.1 | Thromboxane A synthase 1 (TBXAS1) | 3.6 | 9.34E−03 |
| BC096097.2 | Histidine ammonia‐lyase (HAL) | 4 | 6.23E−03 |
| NM_172,160.1 | Methylcrotonoyl‐Coenzyme A carboxylase 1 (alpha) (MCCC1) | 10.6# | 2.53E−03 |
| BC013119.1 | Signal‐induced proliferation‐associated 1 like 2 (SIPA1L2) | 3# | 3.33E−02 |
⁎
signal intensity ratio of two groups.
#
the proteins’ signal intensity ratio is calculated by mean of signal intensity of cancer-free smokers divided by that lung cancer patients, suggesting the proteins has a low level in lung cancer patients vs. cancer-free smokers.
The proteins in bold are chosen for subsequent ELISA validation based on criteria: 1) having differential signals between two the populations with a p ≤ 0.01 and, 2) having signal intensity ratio between the two populations being >10.0.