Table 2.
Univariate and multivariate analysis of variables influencing overall survival.
| Univariate |
Multivariate (final selected model) |
||||
|---|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | Reference category | |
| Overall Survival | |||||
| Age at diagnosis (cat) [45–55] | 1.3107 (0.2645–6.4947) | 0.7404 | 0.951 (0.1739–5.1995) | 0.9537 | ref <45 |
| Age at diagnosis (cat) [55–65] | 5.0751 (1.1962–21.5315) | 0.0276 | 4.9895 (1.1714–21.2524) | 0.0297 | |
| Age at diagnosis (cat) ≥65 | 7.0341 (1.7169–28.8175) | 0.0067 | 6.7727 (1.6466–27.8569) | 0.0080 | |
| pT (no y) 2 + 3 | 1.5778 (0.9549–2.607) | 0.0751 | – | – | ref 1 (1mic+1a/1b/1c) |
| pN (no y) 1a+1mi | 2.1272 (1.3319–3.3974) | 0.0016 | 1.8799 (1.1731–3.0127) | 0.0087 | ref pN = 0 |
| pN (no y) x | 3.1582 (1.4301–6.9743) | 0.0044 | 2.6776 (1.2044–5.9526) | 0.0157 | |
| Histology: LIC | 1.5917 (0.8636–2.9335) | 0.1362 | – | – | ref DIC + other |
| Histology: mixed | 1.2665 (0.4627–3.4669) | 0.6456 | – | – | |
| Grading G2 | 1.4755 (0.8072–2.697) | 0.2062 | – | – | ref G1 |
| Grading G3 | 2.0313 (1.0805–3.8186) | 0.0278 | – | – | |
| In situ histology yes | 0.8089 (0.5086–1.2866) | 0.3705 | – | – | ref no |
| Vascular invasion yes | 0.5942 (0.2744–1.2867) | 0.1867 | – | – | ref no |
| Mol. sub.: Luminal B Her2- | 1.8277 (1.1082–3.0144) | 0.0181 | 1.7757 (1.0621–2.9686) | 0.0285 | ref Luminal A |
| Mol. sub.:Luminal B Her2+ | 1.7622 (0.7296–4.256) | 0.2079 | 2.5225 (1.0298–6.1788) | 0.0430 | |
| Mol. sub.:HR- Her2+ | 2.4369 (0.9408–6.3125) | 0.0666 | 3.0638 (1.1746–7.9912) | 0.0221 | |
| Mol. sub.:TNBC | 3.568 (1.9054–6.6814) | 0.0001 | 3.668 (1.9193–7.01) | 0.0001 | |
| Breast size big | 1.1329 (0.6089–2.1079) | 0.6936 | – | – | ref small |
| Breast size medium | 1.1617 (0.6247–2.1603) | 0.6357 | – | – | |
| Breast size very big | 1.0828 (0.5146–2.2784) | 0.8339 | – | – | |
| Obesity yes | 1.2883 (0.8079–2.0544) | 0.2873 | – | – | ref no |
| Diabetes yes | 2.4485 (1.3524–4.433) | 0.0031 | – | – | ref no |
| Hypertension yes | 1.3116 (0.8488–2.0266) | 0.2219 | – | – | ref no |
| Thyroid illness yes | 0.976 (0.529–1.8007) | 0.9380 | – | – | ref no |
| Smoking (current + ex) | 1.2834 (0.7795–2.1132) | 0.3267 | – | – | ref no |
| Family history yes | 0.9889 (0.6255–1.5634) | 0.9618 | – | – | ref no |
| Nr. of lymph nodes:1 (including 1mic, no x, no y) Nr. of lymph nodes: 2 + 3 |
1.7874 (1.0178–3.1389) 2.9100 (1.5142–5.5923) |
0.0432 0.0014 |
ref = 0 | ||
| Chemotherapy yes | 1.2456 (0.8014–1.9359) | 0.3290 | ref no | ||
| Hormonal therapy yes | 0.5686 (0.3509–0.9213) | 0.0219 | ref no | ||
| Monoclonal antibodies yes | 1.3479 (0.6976–2.6043) | 0.3743 | ref no | ||
| Alcohol consumption yes | 1.6525 (0.7212–3.7865) | 0.2351 | ref no | ||
DIC = Ductal Invasive Carcinoma, LIC = Lobular Invasive Carcinoma, mic = microinvasive, Her2- = Her2 negative, Her2+ = Her 2 positive, HR-Her2+ = Hormone Receptor Negative Her2 Positive, TNBC = Triple Negative Breast Cancer, ref = reference, Mol. Sub. = Molecular Subtype, Nr. = number.