Table 2.
Thermodynamic parameters of the interaction between C2HRNizp1 and PHDvC5HCHNSD1 in the absence and in the presence of a twenty-fold excess of molecules 1–3. ΔG, ΔH, ΔS, stoichiometry (n) and dissociation constants (Kd) as measured by ITC experiments at T = 293.15 K are indicated.
| ΔG (kcal/mol) | ΔH (kcal/mol) | ΔS (cal/mol) | N | Kd (μM) | |
|---|---|---|---|---|---|
| No ligand [18] | −7.3 ± 0.1 | 4.1 ± 0.1 | 38.7 ± 0.1 | 1.1 ± 0.1 | 3.8 ± 0.7 |
| 1 | −5.9 ± 0.1 | 3.6 ± 0.1 | 32.2 ± 0.2 | 0.9 ± 0.1 | 40.5 ± 2.2 |
| 2 | −5.8 ± 0.1 | 2.5 ± 0.2 | 27.8 ± 0.1 | 1.0 ± 0.1 | 54.1 ± 1.1 |
| 3 | −5.9 ± 0.1 | 2.7 ± 0.1 | 29.0 ± 0.2 | 1.0 ± 0.1 |
|