Table 3.
Main functions of software repositories, split by software and trial phase.
| Groupsequentialmethods | Dosemodification/escalation | Sample size adjustment | Adaptive randomization | Bayesianmethods | Biomarker-basedmethods | |
|---|---|---|---|---|---|---|
| Software | ||||||
| JavaScript | – | 1 | – | – | – | – |
| Julia | 1 | – | 1 | 1 | – | 1 |
| Python | 1 | – | – | – | 1 | – |
| R | 48 | 36 | 9 | 8 | 45 | 9 |
| SAS | 3 | 1 | – | 4 | 1 | 1 |
| Stata | 9 | 1 | 1 | – | 3 | – |
| Phase | ||||||
| I | – | 27 | – | – | 21 | – |
| I/II | – | 10 | – | – | 8 | 1 |
| II | 56 | 10 | 10 | 13 | 27 | 10 |
| II/III | 2 | 1 | – | – | 1 | – |
| III | 46 | 2 | 9 | 12 | 14 | 7 |
Each package may belong to multiple categories and cover multiple trial phases.