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. 2020 Nov 25;48(22):12711–12726. doi: 10.1093/nar/gkaa1090

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — A schematic for PrimPol stabilization by deubiquitinase USP36, which promotes replication fork progression following DNA replication stress. Overexpressed USP36 binds to PrimPol and interferes with its K29-linked polyubiquitination and degradation. The PrimPol protein is markedly stabilized by USP36 overexpression and promotes stalled fork restart in the response to DNA replication stress in cancer cells.