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. 2020 Dec 4;48(22):12632–12647. doi: 10.1093/nar/gkaa1149

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — Phylogeny of ATPase and TOPRIM domains associated with type I retrons. (A) The unrooted tree was constructed from an alignment of 1,676 ATPase domain sequences and was obtained with the FastTree program. The tree newick file is provided in Supplementary File S2. The branches corresponding to OLD nucleases, PtuA, and ATPase domains from type I-A, I-B1 and I-B2 retrons are indicated with highlighting in different colors. (B) The unrooted tree was constructed from an alignment of 1167 TOPRIM domain sequences and was obtained with the FastTree program. The newick file is provided as Supplementary File S3. The branches corresponding to OLD nucleases, DnaG primase, topoisomerase II-B (Topo II-B) RNase M5, topoisomerase III (Topo III), topoisomerase I (Topo I), reverse gyrase, RecR, topisomerase II-A (Topo II-A) and GyrB are shown, together with TOPRIM domains from type I-B1, I-B2, I-C1, I-C2 and I-C3 retrons, highlighted in different colors.