Figure 5.

Sequence covariation analysis within the NewPHL family. (A) 577 NewPHL orthologs were subjected to covariation analysis as provided by the GREMLIN webserver (47,55). Whereas the N-terminal catalytic domain (orange) maps to the catalytic domain of photolyases, the C-terminal Z-domain (blue) bears striking similarity for its first 125 amino acids to the antenna-binding domain. (B) Distribution of residues (blue circles) of the catalytic domain, whose covariance strictly depends on residues in the Z-domain (cut-off: scaled score > 0.9).