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. 2020 Dec 14;10(12):125. doi: 10.1038/s41408-020-00393-0

Fig. 2. PA28α regulates multiple myeloma sensitivity to PIs.

Fig. 2

a LP1 cells were transfected with PA28α siRNA for 72 h, cells were then treated with bortezomib for 24 h and MTT assay was performed to analyze cell growth. b LP1 cells were transfected with Flag-PA28α for 48 h, cells were then treated with bortezomib for 24 h, and MTT assay was performed to analyze cell growth. c MTT assay and Annexin V/Propidium Iodide (PI) flow cytometry assay of LP1 PA28α knockdown stable cells under exposure to different concentrations of bortezomib or carfilzomib for 48 h. Western blot was performed to show PA28α expression. *P < 0.05, **P < 0.01, Student’s t test.