Table 3.

Summary of radiomics features for dbPET and wbPET.

	Features	dbPET Median (IQR)	wbPET Median (IQR)	Median difference (95% CI)	P-Value
Morphology	Mesh volume (cm3)	6.08 (2.94–13.65)	19.19 (7.36–26.87)	− 11.00 (− 22.59, − 2.13)	0.006
	Surface area (cm2)	26.12 (15.46–68.29)	51.59 (25.28–92.57)	− 17.76 (− 150.57, 2.66)	0.77
	Sphericity	0.65 (0.54–0.69)	0.70 (0.58–0.74)	− 0.03 (− 3.06, 0.90)	0.43
	Maximum 3D Diameter (cm)	4.24 (2.63–4.80)	43.72 (34.37–72.71)	− 1.13 (− 43.07, 0.22)	0.28
Tumor Intensity	Entropy	7.96 (7.49–9.12)	8.89 (8.02–10.33)	− 1.12 (− 2.53, 0.3)	0.28
	Uniformity	5.1e−3 (2.1e−3–6.5e−3)	2.4e−3 (9.5e−4–4.6e−3)	6.3e−4 (− 0.003, 0.005)	0.70
	Skewness	0.90 (0.83–1.07)	0.59 (0.43–0.76)	0.32 (− 0.11, 0.65)	0.13
	Kurtosis	3.31 (2.74–3.62)	2.69 (2.57–3.31)	0.53 (− 0.63, 2.93)	0.19
	Standard Deviation	1.42 (0.99–2.09)	1.7 (1.22–2.82)	− 0.60 (− 3.06, 0.90)	0.43
GLCM	Contrast	2.6e4 (1.4e4–7.7e4)	1.9e4 (7.2e3–2e5)	6.8e3 (− 3.6e5, 1.1e5)	0.92
	Correlation	0.43 (0.27–0.54)	0.78 (0.76–0.84)	− 0.42 (− 0.60, − 0.25)	0.002
	Inverse Difference	0.03 (0.02–0.04)	0.03 (0.01–0.05)	− 0.01 (− 0.11, 0.01)	0.56
	Normalized Inverse Difference	0.87 (0.84–0.90)	0.92 (0.90–0.93)	− 0.05 (− 0.08, − 0.02)	0.002
	Joint Energy	9.01e−4 (4.5e−4–0.002)	6.5e−4 (2.4e−4–9.7e−4)	5.14e−4 (− 1.86e−5, 8.37e−3)	0.084
	Joint Entropy	10.17 (8.93–11.13)	10.97 (10.03–12.06)	− 0.71 (− 2.30, − 0.15)	0.01
NGTDM	Busyness	0.008 (0.003–0.019)	8.2e−4 (2.8e−4–1.4e−3)	0.004 (− 0.04, 0.01)	0.0840
	Coarseness	0.003 (0.002–0.007)	0.006 (0.003–0.009)	− 0.002 (− 0.005, 0.007)	0.2324
	Complexity	4.6e6 (2e6–3.7e7)	8.7e6 (1.7e6–2.8e8)	− 4.69e6 (− 1.97e9, 5.37e7)	0.7695
	Contrast	31.52 (10.06–116.78)	10.8 (8.05–49.11)	42.24 (− 26.82, 242.48)	0.2754
	Strength	490.9 (248.9–1.6e3)	2.4e3 (1.4e3–6.6e3)	− 0.001 (− 1.4e4, 176.6)	0.1602

Statistical significance, median difference, and 95% confidence intervals were assessed using the Wilcoxon signed-rank test.

GLCM gray-level co-occurrence matrix, NGTDM neighborhood gray-tone difference matrix.