Table 1.
Protein detection in patient tissue and U-RT1 cell block sections by immunohistochemistry and immunocytochemistry.
| Antigen | CLL Bone Marrow | Lymphoma Stomach | Lymphoma Lymph Node | U-RT1 |
|---|---|---|---|---|
| BCL-2 | +++ | +++ | +++ | +++ |
| BCL6 | + | − | − | − |
| CD5 | +++ | − | ++ | + |
| CD10 | − | − | + | − |
| CD20 | +++ | +++ | +++ | ++ |
| CD23 | +++ | + | − | +++ |
| CD30 | n.a. | − | − | −/+ |
| CD38 | ++ | +++ | +++ | − |
| CDK4 | n.a. | − | − | ++ |
| CDK6 | n.a. | − | − | − |
| MYC | + | ++ | + | + |
| Cyclin D1 | − | − | − | − |
| IgD | +++ | − | − | − |
| IgM | +++ | − | − | + |
| Ki-67 | ++ | +++ | +++ | +++ |
| MUM1 | n.a. | − | ++ | ++ |
| P16 | n.a. | − | − | − |
| P53 | n.a. | n.a. | n.a. | − |
| PAX-5 | +++ | +++ | +++ | +++ |
| PD-L1 | n.a. | - | + | + |
| Rb | n.a. | n.a. | n.a. | +++ |
| ZAP-70 | n.a. | − | +++ | − |
Immunohistochemistry panels for U-RT1, gastric lymphoma, lymphoma found in the lymph node, and the underlying chronic lymphatic leukemia all from the same patient. Standard CLL markers were used. The stains for P53 and Rb missing in the lymphomas are due to the amount of tumor tissue available. Results were evaluated as follows: no reaction (−), 30% cells positive (+), 30% to 70% cells positive (++), more than 70% cells positive (+++).
CLL = chronic lymphocytic leukemia.