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. 2020 Nov 24;23(12):101857. doi: 10.1016/j.isci.2020.101857

Figure 1.

Figure 1

Detection of LINC00162 Expression in Bladder Cancer Cells and Tissues

(A) Heatmap analysis results of super-enhancer lncRNA microarray in the UM-UC-3 cell and the SV-HUC-1 cell.

(B) The expression of five upregulated lncRNAs in microarray analysis was detected in SV-HUC-1 and UM-UC-3 cells by q-PCR, ∗p < 0.05.

(C) Genomic structure of LINC00162. LINC00162 is composed of two exons of PICSAR, and PICSAR is located in the chromosome 21q22 region.

(D) Relative expression of LINC00162 in bladder normal epithelial cells and two bladder cancer cell lines. Data are expressed as mean ± standard deviation, n = 3, unpaired t test, ∗p < 0.05.

(E) The scatterplot shows the relative expression of LINC00162 (standardized according to GAPDH expression level) in 32 pairs of bladder cancer and adjacent tissues, n = 32, paired t test, ∗p < 0.05.

(F) Relative expression of LINC00162 in bladder cancer tissues of 32 patients relative to adjacent tissues.

(G) Receiver operating characteristic curve analysis to evaluate the diagnostic value of LINC00162. The area under the curve (AUC) was 0.709 (95% CI: 0.579–0.839).