Table 2a:

Performance Characteristics of Four Phenotype Algorithms using Diagnostic Condition Codes to Determine Chronic Kidney Disease and Atrial Fibrillation on Multiple Datasets using PheValuator. The continuous 3-color heat map for the data in the table was defined as Red (value = 0), Yellow (value = 0.5), and Green (value = 1).

		Chronic Kidney Disease					Atrial Fibrillation
Phenotype Algorithm	Database	Sens	PPV	Spec	NPV		Sens	PPV	Spec	NPV
>=1 X HOI	CCAE	0.798	0.445	0.990	0.998		0.924	0.281	0.990	0.999
	Optum1862	0.822	0.497	0.985	0.997		0.912	0.399	0.989	0.999
	OptumGE66	0.856	0.601	0.888	0.969		0.948	0.478	0.906	0.995
	MDCD	0.903	0.484	0.974	0.997		0.930	0.323	0.984	0.999
	MDCR	0.840	0.501	0.910	0.981		0.956	0.360	0.890	0.997
	PanTher1862	0.711	0.592	0.990	0.994		0.908	0.480	0.991	0.999
	PanTherGE66	0.806	0.575	0.929	0.976		0.930	0.459	0.912	0.994
>= 2 X HOI	CCAE	0.707	0.551	0.994	0.997		0.818	0.341	0.993	0.999
	Optum1862	0.760	0.581	0.990	0.996		0.799	0.463	0.993	0.998
	OptumGE66	0.802	0.653	0.916	0.959		0.887	0.525	0.927	0.989
	MDCD	0.841	0.578	0.983	0.996		0.783	0.386	0.990	0.998
	MDCR	0.757	0.574	0.940	0.973		0.890	0.400	0.914	0.992
	PanTher1862	0.679	0.624	0.992	0.994		0.857	0.514	0.993	0.999
	PanTherGE66	0.778	0.596	0.937	0.973		0.895	0.478	0.922	0.991
>=1 X HOI, In-Patient	CCAE	0.282	0.673	0.999	0.993		0.466	0.390	0.997	0.998
	Optum1862	0.371	0.745	0.998	0.988		0.480	0.511	0.996	0.996
	OptumGE66	0.372	0.794	0.981	0.888		0.569	0.550	0.958	0.961
	MDCD	0.579	0.670	0.992	0.989		0.631	0.419	0.993	0.997
	MDCR	0.417	0.699	0.981	0.940		0.623	0.436	0.948	0.975
	PanTher1862	0.231	0.769	0.999	0.985		0.269	0.545	0.998	0.993
	PanTherGE66	0.296	0.718	0.986	0.922		0.357	0.502	0.972	0.950
1 X HOI, In-Patient, 1st Position	CCAE	0.127	0.837	0.999	0.991		0.359	0.422	0.998	0.997
	Optum1862	0.132	0.895	0.999	0.984		0.313	0.551	0.998	0.995
	OptumGE66	0.093	0.907	0.998	0.848		0.355	0.591	0.978	0.943
	MDCD	0.252	0.861	0.999	0.980		0.444	0.513	0.997	0.996
	MDCR	0.093	0.907	0.998	0.848		0.355	0.591	0.978	0.943
	PanTher1862	0.040	0.901	0.999	0.981		0.136	0.617	0.999	0.992
	PanTherGE66	0.035	0.838	0.999	0.897		0.158	0.560	0.990	0.936

Sens – Sensitivity ; PPV – Positive Predictive Value ; Spec – Specificity; NPV – Negative Predictive Value; Dx Code – Diagnosis code for the phenotype; CCAE - IBM^® MarketScan^® Commercial Claims and Encounters Database, ages 18-62 years; MDCR - IBM^® MarketScan^® Medicare Supplemental and Coordination of Benefits Database, ages 66 years and greater; MDCD - IBM^® MarketScan^® Multi-State Medicaid, ages 18-62 years; Optum1862 - Optum© De-Identified Clinformatics^® Data Mart Database – Date of Death, ages 18-62 years; OptumGE66 - ages 66 years and greater; PanTher1862 - Optum© de-identified Electronic Health Record Dataset, ages 18-62 years; PanTherGE66 - Optum© de-identified Electronic Health Record Dataset, ages 66 years and greater