. Author manuscript; available in PMC: 2020 Dec 15.

Published in final edited form as: J Biomed Inform. 2019 Jul 29;97:103258. doi: 10.1016/j.jbi.2019.103258

Table 4a:

Performance Characteristics of 3 Phenotype Algorithms Replicating Those From Prior Publications to Determine Acute Myocardial Infarction on Multiple Datasets using PheValuator

Comparison	Database	Sens	PPV	Spec	NPV
Wahl	From Paper¹	-	0.884 (95% CI: 0.832, 0.925)	-	-
	CCAE	0.343	0.698	0.999	0.996
	Optum1862	0.323	0.642	0.999	0.995
	OptumGE66	0.359	0.641	0.990	0.970
	MDCD	0.364	0.561	0.996	0.991
	MDCR	0.373	0.636	0.991	0.973
	PanTher1862	0.100	0.642	0.999	0.992
	PanTherGE66	0.129	0.560	0.996	0.968
	Mean:	0.284	0.626	0.996	0.984
Choma	From Paper²	-	0.928 (95% CI: 0.896, 0.952)	-	-
	CCAE	0.332	0.763	0.999	0.996
	Optum1862	0.303	0.716	0.999	0.995
	OptumGE66	0.310	0.701	0.994	0.967
	MDCD	0.324	0.643	0.998	0.991
	MDCR	0.321	0.686	0.994	0.971
	PanTher1862	0.074	0.720	0.999	0.992
	PanTherGE66	0.087	0.628	0.998	0.966
	Mean:	0.250	0.694	0.997	0.983
Cutrona	From Paper³	-	0.860 (95% CI: 0.792, 0.912)	-	-
	CCAE	0.610	0.787	0.999	0.998
	Optum1862	0.565	0.752	0.999	0.997
	OptumGE66	0.430	0.710	0.991	0.973
	MDCD	0.480	0.664	0.997	0.993
	MDCR	0.444	0.692	0.991	0.976
	PanTher1862	0.201	0.700	0.999	0.993
	PanTherGE66	0.180	0.589	0.995	0.969
	Mean:	0.416	0.699	0.996	0.986

Standard codes for acute myocardial infarction (i.e., ICD-9 410.XX) excluding subsequent AMI codes (i.e., ICD-9 410.X2) from an hospital inpatient visit with a length of stay between 3 and 180 days or death if length of stay is less than 3 days (Wahl et al ¹⁷)

Standard codes for acute myocardial infarction from an hospital inpatient visit with a length of stay > 2 days (Choma at al ¹⁸)

Standard codes for acute myocardial infarction in the principal or primary position on facility claims for hospitalizations excluding subsequent AMI codes (Cutrona et al ¹⁹)

Sens – Sensitivity ; PPV – Positive Predictive Value ; Spec – Specificity; NPV – Negative Predictive Value;; CCAE - IBM^® MarketScan^® Commercial Claims and Encounters Database, ages 18-62 years; MDCR - IBM^® MarketScan^® Medicare Supplemental and Coordination of Benefits Database, ages 66 years and greater; MDCD - IBM^® MarketScan^® Multi-State Medicaid, ages 18-62 years; Optum1862 - Optum© De-Identified Clinformatics^® Data Mart Database – Date of Death, ages 18-62 years; OptumGE66 - ages 66 years and greater; PanTher1862 - Optum© de-identified Electronic Health Record Dataset, ages 18-62 years; PanTherGE66 - Optum© de-identified Electronic Health Record Dataset, ages 66 years and greater