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. Author manuscript; available in PMC: 2020 Dec 15.
Published in final edited form as: J Biomed Inform. 2019 Jul 29;97:103258. doi: 10.1016/j.jbi.2019.103258

Table 4b:

Performance Characteristics of Phenotype Algorithms Replicating Those From Prior Publications to Determine Chronic Kidney Disease and Cerebral Infarction on Multiple Datasets using PheValuator

Comparison Database Sens PPV Spec NPV
Nadkarni et al (CKD) Conditions, Procedures, GFR Measurements From Paper1 - 0.960 (95% CI: 0.940, 0.973) - 0.933 (95% CI: 0.909, 0.951)
CCAE 0.001 0.814 0.999 0.989
Optum1862 0.001 0.866 0.999 0.980
OptumGE66 0.002 0.873 0.999 0.806
MDCR 0.001 0.692 0.999 0.895
Mean: 0.001 0.811 0.999 0.918
Nadkarni et al (CKD) Conditions From Paper1 - 0.629 (95% CI: 0.578, 0.677) - 0.543 (95% CI: 0.507, 0.578)
CCAE 0.331 0.626 0.998 0.993
Optum1862 0.310 0.700 0.997 0.986
OptumGE66 0.402 0.890 0.988 0.873
MDCD 0.349 0.700 0.994 0.976
MDCR 0.376 0.666 0.978 0.931
Mean: 0.354 0.716 0.991 0.952
Wahl et al (Stroke) Conditions, >=3 Days LOS From Paper2 - 0.874 (95% CI: 0.820, 0.917) - -
CCAE 0.253 0.607 0.999 0.997
Optum1862 0.247 0.600 0.999 0.996
OptumGE66 0.277 0.635 0.993 0.971
MDCD 0.249 0.589 0.997 0.988
MDCR 0.290 0.566 0.992 0.976
Mean: 0.263 0.599 0.996 0.986
1

Nadkarni et al 20

2

Wahl et al 17

Sens – Sensitivity ; PPV – Positive Predictive Value ; Spec – Specificity; NPV – Negative Predictive Value; HOI – Health Outcome of Interest; CKD – Chronic Kidney Disease; CCAE - IBM® MarketScan® Commercial Claims and Encounters Database, ages 18-62 years; MDCR - IBM® MarketScan® Medicare Supplemental and Coordination of Benefits Database, ages 66 years and greater; MDCD - IBM® MarketScan® Multi-State Medicaid, ages 18-62 years; Optum1862 - Optum© De-Identified Clinformatics® Data Mart Database – Date of Death, ages 18-62 years; OptumGE66 - ages 66 years and greater