The thymus output function of breast cancer model mice was decreased. (A) Changes of the expression of TRECs of each group after 3 weeks and 5 weeks administration. *p<0.05, **p<0.01, 3w vs 5w. Data are means ± SEM. (B) Organ indexes of each group after administration three weeks. Data are means ± SD, n=4. *p<0.05, **p<0.01, vs BALB wt group, #p<0.05, ##p<0.01, vs wt 4T1 group, △p<0.05, △△p<0.01, vs nu 4T1 group. (C) Organ indexes of each group after administration five weeks. Data are means ± SD, n=6. *p<0.05, **p<0.01, vs BALB wt group, #p<0.05, ##p<0.01, vs wt 4T1 group, △p<0.05, △△p<0.01, vs nu 4T1 group.