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. 2020 Nov 30;23(12):101878. doi: 10.1016/j.isci.2020.101878

Figure 1.

Figure 1

Characterization of the Tumor Microbiome and Its Functional Relationship With Carcinogenesis

(A) Nejman et al. characterized the cancer microbiome profile of 1,526 human tumors across seven different tumor types. The presence of bacteria was assessed by bacterial 16S rDNA qPCR.

(B) There is high diversity of microbial species across the tumor types.

(C) Nejman et al. also characterized the prevalence of 19 bacterial species across the different tumor types. Reproduced from Nejman et al. (2020).

(D) Bullman et al. demonstrated persistence of F. nucleatum in patient-derived xenografts over a period of 204 days. Reproduced with permission from Bullman et al. (2017).

(E) Casasanta et al. showed Fusobacterium nucleatum-induced IL-8 and CXCL1 secretion from HCT116 colorectal cancer cells, driving cell migration in vitro using F. nucleatum-conditioned media and that could be blocked by inhibiting bacterial internalization. Reproduced with permission from (Casasanta et al., 2020).

(F) Xia et al. showed increased positive correlation of interactions involving Fusobacterium nucleatum and Hungatella hathewayi and the genes MLH1, APC, PTEN, and CDX2 in colorectal cancer (CC-BY-4.0 (https://creativecommons.org/licenses/by/4.0/)).