Table 1.

Summary of flow and image cytometry studies relating to genomic instability in various cancer types

Cancer type	Method of measuring genomic instability	Number of patients	Outcome Shorter survival/poor prognosis of aneuploid/genomic instable tumors	Reference
Colorectal cancer	Flow cytometry	694	Higher survival rate of diploid tumors	Witzig et al. (1991)
	Flow cytometry	528	Higher survival rate of diploid tumors	Sinicrope et al. (2006)
	Image cytometry	213	Higher survival rate of diploid tumors without metastasis (Dukes’stage A & B)	Bosari et al. (1992)
	Image cytometry	288	Higher survival rate of diploid tumors; Aneuploidy strongest prognostic marker for CRC	Gerling et al. (2010)
	Flow and image cytometry	10,126	Higher survival rate of diploid tumors	Walther et al. (2008)
	Image cytometry	217	Higher survival rate of diploid tumors	Laubert et al. (2013)
	Genotyping of MSI markers	12,782	Higher survival rate of MSI tumors	Guastadisegni et al. (2010)
	Flow cytometry	163	Higher survival rate of diploid tumors	Flyger et al. (1999)
	Image cytometry	219	Higher survival rate of euploid tumors	Bondi et al. (2009)
	Image cytometry	47	Diploid signal count of NCOA3 is associated with a longer adenoma recurrence-free surveillance	Habermann et al. (2011a, b)
	Image cytometry	78	Higher survival rate of diploid tumors; HDAC2 & TXNL1 marker for genomic stability	Gemoll et al. (2011)
Breast cancer	Image cytometry	227	Higher survival rate of diploid tumors	Fallenius et al. (1988)
	Image cytometry	890	Higher survival rate of genomically stable subtypes	Kronenwett et al. (2006)
	Image cytometry	112	Higher survival rate of diploid tumors	Auer et al. (1980)
	Image cytometry	48	12-gene signature predict degree of genomic instability and disease prognostication	Habermann et al. (2009), Mettu et al. (2010)
	Image cytometry	370	Lower survival rate of highly aneuploid tumors	Yildrim-Assaf et al. (2007)
	Image cytometry	599	Single cell aneuploidy as marker for genomic instability and biologic aggressiveness	Sidoni et al. (2001)
	Image cytometry	134	Lower survival rate of tumors with cancer cells with >5c DNA content	Siitonen et al. (1993)
	Flow cytometry	860	Hypertetraploidy as marker for biologic aggressiveness	Pinto et al. (1997)
Endometrial cancer	Flow cytometry	256 and 203	Higher survival rate of diploid tumors	Britton et al. (1989, 1990)
	Flow cytometry	76	Higher survival rate of diploid tumors	Ikeda et al. (1993)
	Image cytometry	358	Higher survival rate of diploid tumors	Lundgren et al. (2002)
	Flow cytometry	174	Higher survival rate of diploid tumors	Susini et al. (2007)
	Flow cytometry	363	Higher survival rate of diploid tumors	Wik et al. (2009)
Ovarian cancer	Flow cytometry	682	Higher survival rate of diploid tumors	Akeson et al. (2009)
	Image cytometry	284	Higher survival rate of diploid tumors	Kristensen et al. (2003)
	Image cytometry	47	Higher survival rate of diploid tumors	Kildal et al. (2004)
Large B-cell lymphoma	H&E staining	54	Lower survival rate of patients with chromosomal instability	Bakhoum et al. (2011)
Oral squamous cancer	FISH	77	Lower survival rate of patients with chromosomal instability	Sato et al. (2010)
Synovial sarcoma	CGH	22	Lower survival rate of patients with specific chromosomal instability	Nakagawa et al. (2006)