. 2020 Dec 10;13:12705–12720. doi: 10.2147/OTT.S220971

Table 4.

Particle Therapy Studies

Authors	Type of Study	Particle	Number of Patients	Dose/Fractionation/Chemotherapy	Overall Survival	Toxicity > G3 (Number of Patients)
Terashima et al, 2012¹²⁵	Mono-centric Prospective; Phase I–II,	Proton	50	P1: 50 GyE/25 fractions (5), P2: 70.2 GyE/26 fractions (5), P3: 67.5 GyE/25 fractions (40), All with concurrent gemcitabine	1-year:76.8% P3 patients: 1-year:78.8%	P1 G3 Anorexia (1) G3 Epigastralgia (1) P2 G3 Anorexia (1) G3 gastric ulcer (1), P3: G3 Anorexia (4) G3 GI ulcer (3); G5: death from GI bleeding (1)
Shinoto et al, 2016¹²⁹	Mono-centric Prospective, Phase I	Carbon ions	71	43.2–55.2 GyE/12 fractions, Gemcitabine	1-year: 73%, 2-year: 35% Median:19.6 months	G3 Anorexia (6), G3 gastrointestinal (1)
Shinoto et al, 2018¹²⁸	Mono-centric retrospective study	Carbon ions	46	55.2 GyE/12fractions, Gemcitabine	2-year: 53% Median:25.1 months	G3 anorexia (1); G3 gastrointestinal (2)
Kawashiro et al, 2018¹¹⁹	Multi-centric retrospective study	Carbon ions	72	52.8 GyE or 55.2 GyE 12 fractions Concurrent Gemcitabine (in 78% pts)	1 -year: 73% 2 -year: 46% Median: 21.5 months	G3 anorexia (2); G3 duodenal-ulcer (1)