Table 1. Characteristics of 27 Infants With SARS-CoV-2 Infectiona.
| Characteristic | No. (%) | P valueb | ||
|---|---|---|---|---|
| Total (N = 27) | Age | |||
| <3 mo (n = 14) | 3-12 mo (n = 13) | |||
| Epidemiologic features | ||||
| Chronologic age, median (IQR), d | 89 (34-193) | 34 (23-65) | 233 (148-285) | |
| Males | 15 (56) | 7 (50) | 8 (62) | .70 |
| Comorbid conditions | 7 (26) | 1 (7) | 6 (46) | .03 |
| Prematurity <37 wk of gestation | 6 (22) | 1 (7) | 5 (38) | .08 |
| Gestational age at birth, median (IQR), wk (n = 15) | 38.6 (34.4-39.2) | 38.8 (38.5-39.6) | 34.0 (30.0-37.0) | .05 |
| Birth weight, median (IQR), g (n = 18) | 3073 (2718-3375) | 3138 (2998-3505) | 2055 (988-2886) | .02 |
| Breastfeeding, No./total No. (%) | 10/22 (45) | 9/14 (64) | 1/8 (13) | <.001 |
| Family contactc | 14 (52) | 8 (57) | 6 (46) | .57 |
| Hospitalization | 10 (37) | 8 (57) | 2 (15) | .05 |
| Mild diseased | 24 (89) | 12 (86) | 12 (92) | .59 |
| Escherichia coli urinary tract infectione | 5 (19) | 4 (29) | 1 (8) | .33 |
| Clinical symptoms | ||||
| Fever (temperature ≥38 °C) | 22 (81) | 10 (71) | 12 (92) | .32 |
| Hemodynamic signsf | 12 (44) | 9 (64) | 3 (23) | .05 |
| Respiratory symptoms | ||||
| Upper tractg | 16 (59) | 6 (43) | 10 (77) | .12 |
| Lower tracth | 10 (37) | 5 (36) | 5 (38) | >.99 |
| Gastrointestinal tract symptomsi | 23 (85) | 13 (93) | 10 (77) | .33 |
| Neurologic symptomsj | 11 (41) | 8 (57) | 3 (23) | .12 |
| Cutaneous symptomsk | 4 (15) | 2 (14) | 2 (15) | >.99 |
| Laboratory and radiologic findings, median (IQR) | ||||
| White blood cell count, /μL (n = 18) | 8700 (7200-13 600) | 10 500 (7600-14 100) | 8600 (5500-8600) | .12 |
| Neutrophil count, /μL (n = 18) | 2800 (1000-4300) | 3100 (2100-8300) | 900 (500-1600) | .03 |
| Lymphocyte count, /μL (n = 18) | 4700 (3600-6000) | 4300 (3200-5800) | 5700 (4700-6000) | .32 |
| Platelet count, ×103/μL (n = 18) | 303 (260-422) | 368 (271-510) | 257 (238-276) | .18 |
| ALT, U/L (n = 9) | 22 (21-54) | 22 (14-54) | 72 (22-122) | .46 |
| CRP >10 mg/dL, No./total No. (%) | 3/12 (25) | 3/9 (33) | 0/3 | .06 |
| Chest radiograph with mild interstitial anomalies, No./total No. (%) | 2/11 (18) | 2/7 (29) | 0/4 | .49 |
Abbreviations: ALT, alanine aminotransferase; CRP, C-reactive protein; IQR, interquartile range; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.
SI conversion factors: To convert white blood cell, neutrophil, and lymphocyte counts to ×109/L, multiply by 0.001; platelet count to ×109/L, multiply by 1.0; ALT to μkat/L, multiply by 0.0167; and CRP to mg/L, multiply by 10.
The characteristics of the analyzed population include those of the 2 patients from other hospitals; however, the hospitalization rate should not be compared with the rate of hospitalization reported in the literature.6
P < .05 was considered statistically significant.
Family contact was defined by a contact with a symptomatic or laboratory-confirmed family member.
Mild disease was defined using Dong et al criteria.5
Defined by urine culture with greater than 100 000 colony-forming units by catheterization.
Defined as tachycardia on admission or need for fluid resuscitation.
Defined as cough, pharyngitis, nasal congestion, rhinorrhea, or sneezing.
Defined as wheezing, increased work of breathing, tachypnea (respiratory rate, >60/min), apnea, or oxygen saturation less than 94%.
Defined as abdominal pain, diarrhea, vomiting, increased regurgitation, feeding difficulties, or jaundice.
Defined as irritability, drowsiness, hypotonia, or seizure.
Defined as a maculopapular rash on any part of the body.