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. Author manuscript; available in PMC: 2020 Dec 15.
Published in final edited form as: Nano Lett. 2019 Oct 7;19(11):7691–7702. doi: 10.1021/acs.nanolett.9b02592

Figure 2: KIF20A inhibition softens the cytoplasm of both low and high grades bladder cancer cells.

Figure 2:

(A) Average intracellular relaxation curves for control RT112 (blue) and KU (orange) cells for control and for cells treated with the KIF20A inhibitor paprotrain (light blue, light orange). (B-C) Rigidity index, bead step displacement, storage modulus G’ and loss modulus G” in control and KIF20A inhibited RT112 cells (B) or KU cells (C). Data are averages from N=36 and 21 cells for control and KIF20A inhibited RT112 cells and from N=60 cells in both control and KIF20A inhibited KU cells. Error bars represent standard errors. P values are determined from Student’s t- test for unpaired samples with respect to control cells (*** p<0.001; ** p< 0.01; * p<0.05; and n.s. p>.05 not significant).