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. 2020 Dec 8;15(11):755–761. doi: 10.2217/fvl-2020-0132

Figure 2. . Clearance of rabies virus from the CNS requires Type 1 immunity.

Figure 2. 

(A) Infection with a live-attenuated rabies vaccine induces the recruitment of Th1 cells in the brain and leads to the production of virus-killing IgG2a antibodies. (B) Infection with a killed vaccine induces the recruitment of Th2 cells. These cells are inactive in the CNS, severely curtailing the production of virus-killing antibodies.

EC: Endothelial cell; NO: Nitric oxide; RABV: Rabies virus; Th1: CD4+ T helper cell.