Table 1. . Memory immune cell subsets.
Subset name | Location | Blood trafficking | Lymph node trafficking | Function |
---|---|---|---|---|
Tcm | Lymphoid organs | Yes | Yes | Enhance likelihood of specific T cell–APC encounters and magnitude of the secondary immune response |
Tem | Nonlymphoid organs | Yes | No | Effector function in chronic and secondary reinfection |
Trm | Nonlymphoid organs | No | No | Direct tissue immune response and immune surveillance |
Bm | Germinal center lymphoid organs | Yes | Yes | Secondary humoral immune response |
This table summarizes the main subsets of immune memory cells with their localization and functions.
APC: Antigen-presenting cell; Bm: Memory B lymphocyte; Tcm: Central memory T cell; Tem: Effector memory T cell; Trm: Tissue-resident memory T cell.