Table 2. Statistically Significant Associations Between SNVs and Changes in Body Weight, BMI, and BMI-SDS per Week During the Intervention.
SNV | Chr | Position | Effect allelea | Other allele | β Coefficient (95% CI)b | P value | Corr P value | Effect allele frequency | Gene30,c | No. |
---|---|---|---|---|---|---|---|---|---|---|
SNV association with body weight change | ||||||||||
rs13201877 | 6 | 137.717.234 | G | A | −0.073 (−0.106 to −0.039) | 2.39 × 10−5 | .001 | 0.210 | IFNGR1 | 1184 |
rs10733682 | 9 | 128.500.735 | A | G | −0.041 (−0.065 to −0.018) | 6.37 × 10−4 | .04 | 0.516 | LMX1B | 1194 |
rs7164727 | 15 | 70.881.044 | T | C | 0.047 (0.021 to 0.073) | 4.02 × 10−4 | .02 | 0.633 | LOC100287559 | 1194 |
rs12940622 | 17 | 76.230.166 | G | A | 0.054 (0.029 to 0.078) | 1.86 × 10−5 | .001 | 0.565 | RPTOR | 1194 |
rs2836754 | 21 | 39.213.610 | C | T | −0.047 (−0.072 to −0.023) | 1.51 × 10−4 | .01 | 0.575 | ETS2 | 1190 |
SNV association with BMI change | ||||||||||
rs13201877 | 6 | 137.717.234 | G | A | −0.022 (−0.034 to −0.011) | 1.48 × 10−4 | .01 | 0.210 | IFNGR1 | 1184 |
rs2836754 | 21 | 39.213.610 | C | T | −0.015 (−0.024 to −0.007) | 2.84 × 10−4 | .02 | 0.575 | ETS2 | 1190 |
SNV association with BMI-SDS change | ||||||||||
rs13078960 | 3 | 85.890.280 | G | T | 0.003 (0.002 to 0.005) | 2.52 × 10−5 | .001 | 0.268 | CADM2 | 1047 |
rs13107325 | 4 | 103.407.732 | T | C | 0.004 (0.002 to 0.006) | 1.67 × 10−4 | .01 | 0.139 | SLC39A8 | 1191 |
rs11170468 | 12 | 37.716.315 | A | C | 0.003 (0.001 to 0.004) | 1.05 × 10−4 | .01 | 0.700 | CPNE8 | 1197 |
rs9925964 | 16 | 31.037.396 | A | G | −0.002 (−0.003 to −0.001) | 3.48 × 10−4 | .02 | 0.584 | KAT8 | 1186 |
Abbreviations: A, adenosine; BMI, body mass index; C, cytosine; Chr, chromosome; Corr, corrected; G, guanine; SDS, standard deviation score; SNV, single-nucleotide variant; T, thymine.
Provides the effect estimates against the other alleles, which serves as reference.
Standardized regression coefficient.
Genes were provided according to Illumina annotation.