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. 2020 Dec 14;175(1):e205142. doi: 10.1001/jamapediatrics.2020.5142

Table 2. Statistically Significant Associations Between SNVs and Changes in Body Weight, BMI, and BMI-SDS per Week During the Intervention.

SNV Chr Position Effect allelea Other allele β Coefficient (95% CI)b P value Corr P value Effect allele frequency Gene30,c No.
SNV association with body weight change
rs13201877 6 137.717.234 G A −0.073 (−0.106 to −0.039) 2.39 × 10−5 .001 0.210 IFNGR1 1184
rs10733682 9 128.500.735 A G −0.041 (−0.065 to −0.018) 6.37 × 10−4 .04 0.516 LMX1B 1194
rs7164727 15 70.881.044 T C 0.047 (0.021 to 0.073) 4.02 × 10−4 .02 0.633 LOC100287559 1194
rs12940622 17 76.230.166 G A 0.054 (0.029 to 0.078) 1.86 × 10−5 .001 0.565 RPTOR 1194
rs2836754 21 39.213.610 C T −0.047 (−0.072 to −0.023) 1.51 × 10−4 .01 0.575 ETS2 1190
SNV association with BMI change
rs13201877 6 137.717.234 G A −0.022 (−0.034 to −0.011) 1.48 × 10−4 .01 0.210 IFNGR1 1184
rs2836754 21 39.213.610 C T −0.015 (−0.024 to −0.007) 2.84 × 10−4 .02 0.575 ETS2 1190
SNV association with BMI-SDS change
rs13078960 3 85.890.280 G T 0.003 (0.002 to 0.005) 2.52 × 10−5 .001 0.268 CADM2 1047
rs13107325 4 103.407.732 T C 0.004 (0.002 to 0.006) 1.67 × 10−4 .01 0.139 SLC39A8 1191
rs11170468 12 37.716.315 A C 0.003 (0.001 to 0.004) 1.05 × 10−4 .01 0.700 CPNE8 1197
rs9925964 16 31.037.396 A G −0.002 (−0.003 to −0.001) 3.48 × 10−4 .02 0.584 KAT8 1186

Abbreviations: A, adenosine; BMI, body mass index; C, cytosine; Chr, chromosome; Corr, corrected; G, guanine; SDS, standard deviation score; SNV, single-nucleotide variant; T, thymine.

a

Provides the effect estimates against the other alleles, which serves as reference.

b

Standardized regression coefficient.

c

Genes were provided according to Illumina annotation.