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Structure comparison between HCoV-NL63 and SARS-CoV-2 spike. (a) Comparison of our structure with SARS-CoV-2 spike in closed state (PDB ID: 6VXX) in two different views. Different domains and the linker (Lk) between domains A and B are indicated in different colors. (b) Zoom-in view to show the interactions between domain A and domain B in the HCoV-NL63 spike protein. (c) Extracted densities of the S2 fusion machinery region with models fitted.
