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Structural comparison of domains in HCoV-NL63 and SARS-CoV-2 spikes. (a) Ribbon diagram of the spikes. Each domain is shown in different colors. (b) Structure-based alignment of corresponding domains (PDB ID: 6VXX for A′, C′, D′ and S2′), analysed by TM-align (Zhang and Skolnick, 2005). For domain B–B′ comparison, PDB ID: 6VW1 was used for domain B′ because it has receptor-binding motif (outlined in dotted ellipse).
