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. 2020 Oct 8;2020:7814628. doi: 10.1155/2020/7814628

Table 1.

PHB1 function Location Subcellular localization Pathophysiology Reference
Oxidative stress regulation β-Cells Mitochondria Type 2 diabetes Lee et al., FEBBS J, 2010.
Oxidative stress regulation Intestinal epithelial cells Mitochondria Inflammatory bowel disease Kathiria e al., Plos One, 2010.
α-SMA regulation Renal cells Mitochondria Tubulointerstitial lesions Zhou et al., J of Recep and Signal Trans, 2013.
Oxidative stress regulation Cardiomyocytes Mitochondria Myocardium damage Liu et al., Cell Stress Chaperone, 2009.
Oxidative stress regulation Hepatocytes Mitochondria HCV Ivanov et al., Viruses, 2013.
Combating inflammation Lungs Mitochondria COPD Soulitzis et al., Resp. Med, 2012.
P-53, Rb tumor regulator Cancer cells Nucleus Cancer Fusaro et al., JBC, 2003.
Synaptic movement Neural cells Mitochondria/nucleus Schizophrenia Bemstein et al., Neuromol Med, 2012