Figure 3.

AD16 treatment reduces amyloid plaque deposition in AD mice. Nine-month-old male APP/PS1 mice were either orally dosed with vehicle or AD16 for 3 months. Representative staining of ThS positive amyloid plaque in the cortex (A) and hippocampus (B) of the APP/PS1 group and AD16 treated group. Quantification of total areas (C,D) and numbers (E,F) of plaques in whole brains of AD mice receiving AD16 or vehicle in the hippocampus and cortex (n = 5 per group). Scale bar: 200 μm. Statistical comparisons were performed by unpaired Student’s t test. Data are presented as means ± SD; ***p < 0.001.