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. 2020 Nov 18;3(6):1100–1110. doi: 10.1021/acsptsci.0c00073

Figure 4.

Figure 4

AD16 alleviates microglial activation close to amyloid deposition but does not alter microglia number. Nine-month-old male APP/PS1 mice were either orally dosed with vehicle or AD16 for 3 months. Representative costaining of Iba-1 and ThS positive amyloid plaque in the hippocampus of APP/PS1 group (A) and AD16 treated group (B). Quantification of area (C) and number (D) of Iba-1 positive microglia close to amyloid deposition (n = 5 per group). Scale bar: 50 μm. Statistical comparisons were performed by unpaired Student’s t test. Data are presented as means ± SD; ***p < 0.001.