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. 2020 Jul 31;3(6):1063–1068. doi: 10.1021/acsptsci.0c00075

Figure 3.

Figure 3

Unknown-1 (mitragynine pseudoindoxyl) and unknown-2 formation upon 7-HMG incubation with the mouse, rat, dog, cynomolgus monkey, and human plasma. Two unknown peaks (Unknown-1 and -2) were detected having mass transitions similar to that of 7-HMG. These are represented as the concentration of unknown-1 (mitragynine pseudoindoxyl, top) and ratio of unknown-2 to internal standard (IS) peak area (bottom) versus time. The inset in the top panel represents the concentration of unknown-1 (mitragynine pseudoindoxyl) in species other than human. All values are plotted as mean ± SD (n = 3).