Table 1.
Adult Lung Transplant Donor Characteristics by Era (Transplants: January 1992–June 2018)
| Characteristic | Jan 1992–Dec 2000 (N = 11,796) |
Jan 2001–Dec 2009 (N = 21,806) |
Jan 2010–June 2018 (N = 33,891) |
p-value |
|---|---|---|---|---|
| Geographic location | <0.0001 | |||
| Europe | 3,751 (31.8)% | 7,818 (35.9)% | 12,414 (36.6)% | |
| North America | 7,324 (62.1)% | 12,545 (57.5)% | 18,594 (54.9)% | |
| Other | 721 (6.1)% | 1,443 (6.6)% | 2,883 (8.5)% | |
| Age (years) | 30 (15–54) | 37 (16–60) | 40 (17–65) | <0.0001 |
| Male | 61.9% | 56.9% | 56.2% | <0.0001 |
| Height (cm) | 173.0 (157.0–188.0) | 172.7 (157.0–188.0) | 172.0 (155.0–188.0) | <0.0001 |
| BMI (kg/m2) | 23.3 (18.2–31.0)a | 24.2 (18.8–33.1) | 25.1 (19.2–35.5) | <0.0001 |
| Blood type | 0.1946 | |||
| A | 39.1% | 38.8% | 38.5% | |
| AB | 2.3% | 2.4% | 2.3% | |
| B | 9.9% | 10.0% | 10.6% | |
| O | 48.6% | 48.7% | 48.6% | |
| Cause of death | ||||
| Anoxia | 3.5% | 7.9% | 19.8% | <0.0001 |
| CVA/stroke | 38.4% | 44.7% | 41.2% | |
| Head trauma | 49.7% | 44.5% | 36.0% | |
| Other | 8.3% | 2.9% | 3.0% | |
| CMV antibody positive | 55.3% | 60.4% | 61.6% | <0.0001 |
| EBV antibody positive | — | 91.6%b | 93.7% | <0.0001 |
| Hep B antibody positive | 2.4% | 2.5% | 2.6% | 0.6759 |
| Hep C antibody positive | 0.6% | 0.1% | 0.6% | <0.0001 |
| Smoking history | 31.7% | 20.7% | 12.1% | <0.0001 |
| Alcohol use | — | 12.8%b | 14.6% | 0.0001 |
| Cocaine use | — | 10.8% | 14.3% | <0.0001 |
| Other drugs use | — | 28.1% | 40.7% | <0.0001 |
| Diabetes | 2.3%a | 4.6% | 7.2% | <0.0001 |
| Hypertension | 12.4%a | 18.4% | 24.0% | <0.0001 |
| PO2 (mm Hg) | — | 424.0 (115.0–578.4)c | 409.0 (109.0–563.0) | <0.0001 |
Abbreviations: BMI, body mass index; CVA, cerebrovascular accident; CMV, cytomegalovirus; EBV, Epstein-Barr virus; Hep B, hepatitis B; Hep C, hepatitis C; PO2, partial pressure of oxygen.
Summary statistics excluded transplants with missing data.
Continuous factors are expressed as median (5th–95th percentiles).
Comparisons for categorical variables were made using the chi-square statistic.
Comparisons for continuous variables were made using the Wilcoxon test.
a
Based on April 1994–December 2000 transplants.
b
Based on April 2006–December 2009 transplants.
c
Based on July 2004–December 2009 transplants.