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Evolution of the BUN (panel a) and the serum creatinine (panel b) after 10 or 11 Gy PBI/BM5. There is an early acute increase in BUN or serum creatinine, then a period during which there was little or no azotemia at euthanasia, followed by a chronic phase of progressively higher azotemia that was greatest at the end of the 180-day study. The gray dotted lines indicate the normal BUN or serum creatinine concentrations.
