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. 2020 May 6;88(1):123–136. doi: 10.1002/ana.25749

Figure 5.

Figure 5

Restoration of function following acute and chronic nimodipine administration. (A) Shows the score for hindlimb dysfunction (one point assigned for gait, toe spreading, hind limb paresis [left and right] and hind limb paralysis [left and right]) in the 4 days following a single administration of vehicle or drug. (B) Shows scores for neurological deficit in animals receiving chronic nimodipine administration (subcutaneously via Alzet mini pumps) between 1 and 8 days after the onset of disease; indicated by shading in the figure. Animals were assessed using a 10‐point scale where a score of 6 signifies an inability to walk, and 8 denotes hind limb paralysis. Data presented as mean ± SEM. Stated p values reflect the outcome following a 2‐way repeated measures ANOVA in A and B. *p < 0.05, **p < 0.01, ***p < 0.001; Bonferroni’s multiple comparison test, A: EAE + drug n = 20, EAE + vehicle n = 17; B: EAE + drug n = 13, and EAE + vehicle n = 13). ANOVA = analysis of variance; EAE = experimental autoimmune encephalomyelitis. [Color figure can be viewed at www.annalsofneurology.org]