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. 2020 Dec 14;21:577. doi: 10.1186/s12859-020-03922-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Fusion annotations generated by annoFuse a Distribution of intra- and inter-chromosomal fusions across histologies. b Transcript frame distribution of fusions detected by Arriba and STAR-Fusion algorithms. c Bubble plot of gene partner distribution with respect to ENSEMBL biotype annotation (Size of circle proportional to number of genes). d Barplots representing the distribution of kinase groups represented in the PBTA cohort annotated by gene partner. (Alpha_kinase = Alpha-kinase family, Hexokinase_2 = Hexokinase, PI3_PI4_kinase = Phosphatidylinositol 3- and 4-kinase, Pkinase = Protein kinase domain, Pkinase_C = Protein kinase C terminal domain, Pkinase_Tyr = Protein tyrosine kinase). e Bubble plot representing the distribution of fused genes as oncogenes, tumor suppressor genes, kinases, COSMIC, predicted and curated transcription factors (Size of circle proportional to number of genes). Genes belonging to more than one category are represented in each. In all panels except for B, fusion calls were merged from both STAR-Fusion and Arriba