Figure 14.
(A) Agonist potency and intrinsic activity of AL-8810 vs the full-agonist cloprostenol. (B,C) Schild analysis of the antagonist potency of AL-8810 vs fluprostenol-induced [3H]-IPs accumulation in A7r5 rat aortic cells in vitro. (D) AL-8810 concentration-dependently antagonized the functional activity of bimatoprost within a few seconds. (E) AL-8810 antagonized the functional responses to various FP-receptor agonists in a concentration-dependent manner. Overall, the antagonist potency of AL-8810 against a range of FP-agonists in various assay systems was 734 ± 228 nM. While not highly potent, it has proven very useful in clarifying the role of FP-receptors and/or endogenous and exogenous FP-receptor agonist in numerous systems in vitro and in vivo. Panels A–E are reproduced/modified with permission from refs (152 and 233). Copyright 1999 American Society for Pharmacology and Experimental Therapeutics and 2019 Wiley.