Figure 5.

This montage depicts the relative affinity and selectivity of olopatadine for H₁–H₃ receptors subtypes (A), and the ability of histamine to increase production of [³H]-IPs in isolated h-TM cells and the noncompetitive antagonism of these responses by different concentrations of olopatadine (B). Panel A reproduced with permission from ref (29). Copyright 1996 Mary Ann Liebert Publishing Inc. Panel B reproduced with permission from ref (30). Copyright 1996 American Society for Pharmacology and Experimental Therapeutics.