Table 10. FR-190997 (a Nonpeptide BK Agonist) Promotes UVSC Outflow of AQH from OHT Eyes of Ketamine-Sedated Cynomolgus Monkeysa.
| baseline |
T.O.
treatment with FR-190997 |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| normotensive eye OD | n | hypertensive eye OS | n | stats. p-values | hypertensive eye OS | n | .stats. p-values | ||
| Fa | 1.63 ± 0.54 | 12 | 1.54 ± 0.80 | 12 | 0.50 | Fa | 1.48 ± 0.53 | 12 | 0.79 |
| Cfl | 0.42 ± 0.21 | 9 | 0.16 ± 0.17** | 12 | 0.00** | Cfl | 0.18 ± 0.16 | 9 | 0.47 |
| Cton | 0.22 ± 0.14 | 12 | 0.15 ± 0.09 | 10 | 0.21 | Cton | 0.17 ± 0.11 | 9 | 0.59 |
| Fufl | 0.16 ± 0.51 | 7 | 0.47 ± 0.57 | 11 | 0.14 | Fufl | 1.23 ± 0.91 | 9 | 0.00** |
| Futon | 0.48 ± 0.99 | 12 | 0.37 ± 1.04 | 9 | 0.46 | Futon | 1.45 ± 0.45 | 10 | 0.03* |
| ACvol | 76.0 ± 11.3 | 12 | 79.9 ± 9.12 | 12 | 0.16 | ACvol | 79.8 ± 9.2 | 12 | 0.74 |
| CCT | 0.48 ± 0.03 | 12 | 0.48 ± 0.03 | 12 | 0.36 | CCT | 0.48 ± 0.03 | 12 | 0.74 |
a
Note that only UVSC outflow of AQH (determined by 2-methods) is enhanced by FR-190997 in this monkey model of OHT. However, this drug also promoted TM-mediated conventional outflow of AQH as demonstrated in ex-vivo perfused porcine eyes (ref (218)). Data taken from ref (7). The asterisks (∗) indicate statistical significance.