TABLE 1:
Baseline characteristics
| Prenatal surgery N = 91 | Postnatal surgery N = 92 | |
|---|---|---|
| Fetal sex female | 42 (46.2) | 57 (62.0) |
| Gestational age at randomization, wk | 23.7 ± 1.4 | 23.9 ±1.3 |
| Maternal age at screening, wk | 29.2 ± 5.2 | 28.7 ± 4.8 |
| Race/ethnicity | ||
| White non-Hispanic | 85 (93.4) | 86 (93.5) |
| Black non-Hispanic | 1 (1.1) | 1 (1.1) |
| Hispanic | 3 (3.3) | 4 (4.3) |
| Other | 2 (2.2) | 1 (1.1) |
| Married | 84 (92.3) | 86 (93.5) |
| Schooling, y | 14.9 ± 1.7 | 14.9 ±1.7 |
| Body mass index at screening | 26.3 ± 3.7 | 26.3 ± 3.9 |
| Current smoker | 6 (6.6) | 5 (5.4) |
| Nullipara | 37 (40.7) | 37 (40.2) |
| Previous uterine surgeries, including cesarean | 12(13.2) | 11 (12.0) |
| Cervical length, transvaginal, mm | 39.5 ± 7.6 | 39.4 ± 5.9 |
| Anterior placenta | 43 (47.3) | 39 (42.4) |
| Lesion level, ultrasound | ||
| Thoracic | 4 (4.4) | 3 (3.3) |
| L1-L2 | 25 (27.5) | 13(14.1) |
| L3-L4 | 37 (40.7) | 54 (58.7) |
| L5-S1 | 25 (27.5) | 22 (23.9) |
| Lesion level <L3, ultrasound | 62 (68.1) | 76 (82.6) |
| Clubfoot, ultrasound | 24 (26.4) | 19(20.7) |
| Severe hindbrain herniation | 27 (29.7) | 23 (25.0) |
Data presented as no. of patients (%) or mean ± SD unless otherwise stated.
Farmer et al. Management of Myelomeningocele Study. Am J Obstet Gynecol 2018.