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. 2020 Dec 14;39:285. doi: 10.1186/s13046-020-01801-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — In vivo behavior of xenogeneic BRAF-mutated and BRAF wt CRC. a Quantitative time-course analysis of mice injected with luciferase-tagged BRAF^V600E (top) and BRAF wt CCSCs (middle and bottom). The progression of human CRCs was monitored from 3DPT (left) next to the end-stage disease typical of each CCSCs injected. b Histologic analysis, as expressed by H&E staining, revealing features of human serrated CRC with villiform architecture, micropapillary clusters and signet ring cells in BRAF^V600E lesions (top) while marked nuclear atypia and hemorrhagic necrosis (middle and bottom) were detected in BRAF wt CRCs. c OCT-embedded lung sections (left) marked with H&E (middle) depicting pulmonary lesions (arrowhead) in mice infused with BRAF^V600E CCSCs into the lateral tail-vein (n = 3 mice per groups). Widespread immunoreactivity for the human nuclei marker in BRAF^V600E lesions is shown (right). Scale bars, 1000um, 100um and 50um