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. 2020 Dec 14;39:285. doi: 10.1186/s13046-020-01801-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — BRAF^V600E CRC exhibits specific bacterial markers and a typical functional microbiota composition. Gut microbiota relative abundance (% similarity) at the phylum (a-b) and genus level (c-d) in gut microbiota of mice carrying BRAF^V600E and BRAF wt CRC and controls at 7 DPT (a-c) and 43 DPT (b-d). e Significative relative abundance of predicted function (mean proportions %) and different abundance of predicted function (difference in mean proportion %) for specific KEGG modules level 2 in pairwise comparisons between controls, BRAF^V600E (left; top) and BRAF wt CRCs (right) or between the two CRC groups (left; bottom). FDR-adjusted p value (q value) from Mann-Whitney test are shown